Our focus is on understanding the intricate workings of the immune system and its role in maintaining a balanced state of health and protection. We delve into the essential elements that regulate and execute immune responses to safeguard against both internal and external threats, particularly infections. In addition to immunity, we investigate a fascinating phenomenon known as 'Tolerance.' This mechanism actively induces a state of non-responsiveness within the immune system toward various substances that could otherwise trigger immune reactions. Maintaining a delicate balance between these immune compartments, known as 'Immunological homeostasis,' is crucial for overall well-being. Disruptions in this equilibrium can lead to inflammation, driving a wide range of human diseases and conditions, including autoimmune diseases, cancer, and potentially, neurodevelopmental disorders.
Our team is passionately engaged in unraveling novel mechanisms that control the function and development of immune cells. We explore how the breakdown of these mechanisms contributes to the onset and progression of inflammatory disorders. Additionally, we are dedicated to identifying the factors that impact immunological homeostasis in both normal and disease conditions, with a particular focus on host factors (especially immune and neuronal) and bacteria-factors. Ultimately, our goal is to translate this knowledge into potential treatments for human inflammatory disorders such as autoimmunity, cancer, and neurodevelopmental disorders.
We welcome highly motivated students and postdoctoral candidates to join us in our research endeavors. If you are interested, please don't hesitate to send an email to aspirationpassion@gmail.com.
